Table S1.
Combined evaluation on cells
| Groups (µM) | DTX-Ms | 1.25 | 2.50 | 5.00 | 10.0 | 20.0 | 40.0 |
|---|---|---|---|---|---|---|---|
| Tranilast | 25 | 50 | 100 | 200 | 400 | 800 | |
| 4T1 | q | 0.862N | 0.786− | 0.708− | 0.686− | 0.993N | 1.07N |
| 3T3 | 0.898N | 1.00N | 0.820− | 0.924N | 0.960N | 0.966N | |
| 4T1/3T3 | 50.8+ | 9.36+ | 1.35+ | 1.12N | 1.04N | 0.994N | |
| d-CAF | 1.64+ | 1.17+ | 1.08N | 1.04N | 0.948N | 0.877N |
Notes:
−
(q,0.85) means two drugs manifest antagonism;
N
(0.85≤q<1.15) means two drugs have an addictive effect;
+
(q≥1.15) means two dugs behaved synergistically.
Abbreviations: DTX-Ms, docetaxel micelles; d-CAF, detached cancer-associated fibroblast.