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. 2018 Oct 9;8:14999. doi: 10.1038/s41598-018-33403-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Platelet response to thrombin in platelets from HIV-infected individuals under stable cART and healthy volunteers. (A,B) The percentage of platelets with P-selectin surface expression (A) and the mean fluorescence intensity (MFI) for P-selectin labeling (B) on platelets from healthy subjects (control) or from HIV-infected individuals under viral control (HIV-1 viral load < 50 copies/ml in the peripheral blood) after stimulation with thrombin (0.05 U/mL, 0.1 U/mL, 0.2 U/mL and 0.4 U/mL). (C,D) The concentration of RANTES (C) or thromboxane B₂ (D) in the supernatant of platelets from control or HIV-1-infected subjects stimulated with each concentration of thrombin. The dots indicate the mean ± standard error of the mean of 5–10 HIV-infected individuals or healthy volunteers. Representative histograms are shown. The asterisk (*) signifies p < 0.05 between platelets from control or healthy volunteers stimulated with the same concentration of thrombin.