Fig. 1.

Metastatic ACC has a higher mutation burden compared to primary ACC. Total number of mutations per megabase in each tumor sample of both metastatic and primary ACC (TCGA). Each bar on x-axis represents a patient or a tumor sample (a). Total mutations per megabase in metastatic lung ACC and its counterpart primary ACC tumor from the same patient (b). Metastatic ACC mutation rate compared to other cancer types including primary ACC (TCGA) (c). Mutation rate in the primary ACC (TCGA) based on tumor stage (d). Relative proportions of the six possible base-pair mutations in 33 metastatic ACC (e) and primary ACC (f). The top genes that are frequently mutated in metastatic (g) and primary ACC (h)