Table 1.
The conserved targets for S-bacillithiolation and their available crystal structures.
| Protein | Organism | Related structures (PDB ID) | Cysteine residues | Function of the cysteine residue | Confirmed post-translational modificationa |
|---|---|---|---|---|---|
| AldA | Staphylococcus aureus | 3TY7 | C279 | active site residue | S-bacillithiolation |
| GapDH | Staphylococcus aureus | 3LC7 | C96 | - | - |
| 3LVF | C151 | active site residue | S-bacillithiolation, overoxidation | ||
| 5T73 | |||||
| GuaB | Staphylococcus aureus | - | C307 | active site | S-bacillithiolation |
| C326 | - | S-bacillithiolation | |||
| GuaB | Bacillus anthracis | 3TSB | C308 | active site | S-bacillithiolation |
| 3USB | C327 | - | S-bacillithiolation | ||
| 3TSD | |||||
| MetE | Staphylococcus aureus | - | C632 | zinc-binding site | - |
| C715 | zinc-binding site | S-bacillithiolation | |||
| MetE | Streptococcus mutans | 3L7R | C632 | zinc-binding site | - |
| 3T0C | C715 | zinc-binding site | S-bacillithiolation | ||
| PpaC | Staphylococcus aureus | 4RPA | C110 | - | overoxidation |
| C118 | - | - | |||
| C158 | - | S-bacillithiolation, overoxidation | |||
| SarZ | Staphylococcus aureus | 3HRM | C13 | redox-active | S-bacillithiolation |
| 3HSE | |||||
| 3HSR |
a
Also if confirmed in other species.