Table 2.
Patients with discrepant IHVWM and H5VWM
| ID | PROPOSED CLASSIFICATION | VWF:Ag | VWF Ac | Ratio | IHVWM | H5VWM | LMWM | IMWM | HMWM | MUTATION |
|---|---|---|---|---|---|---|---|---|---|---|
| P5 | Normal VWF | 72 | 57 | 0.79 | QNORM | RHWMW | 30.8 | 35.6 | 33.6 | UNK |
| P10 | Normal VWF | 115 | 87 | 0.76 | QNORM | RHMWM | 39.5 | 31.4 | 29.1 | UNK |
| P119 | Normal VWF | 102 | 82 | 0.80 | QNORM | RHWMW | 38.5 | 39.6 | 21.9 | p.P1337L |
| B7 | Normal VWF | 305 | 277 | 0.91 | RHMWM | QNORM | 30.9 | 30.4 | 38.7 | UNK |
| B11 | Normal VWF | 154 | 108 | 0.70 | RHMWM | QNORM | 28.9 | 34.1 | 37.0 | UNK |
| P64 | 1 | 20 | 13 | 0.65 | QNORM | RHMWM | 36.4 | 30.9 | 32.7 | p.C1130F |
| P65 | 1 | 20 | 18 | 0.90 | QNORM | RHMWM | 49.3 | 25.4 | 25.3 | p.C1130F |
| P70 | 1 | 21 | 16 | 0.76 | RHMWM | QNORM | 27.9 | 35.2 | 36.9 | p.P1266Q/p.F1501S |
| P205 | 1 | 45 | 35 | 0.78 | RHMWM | RHMWM | 43.2 | 36.6 | 20.2 | p.P1337L |
| P213 | 1 | 62 | 40 | 0.65 | RHMWM | RHMWM | 43.3 | 35.8 | 20.9 | p.P1337L |
| P94 | 2A | 20 | 11 | 0.55 | RHMWM | QNORM | 27.1 | 35.4 | 37.5 | p.R1374C |
| P96 | 2A | 24 | 10 | 0.42 | RHMWM | QNORM | 32.1 | 28.1 | 39.8 | p.R1374H |
| P111 | 2A | 23 | 10 | 0.43 | RHMWM | QNORM | 45.6 | 16.1 | 38.3 | p.R1374C |
| B8 | 2A | 27 | 16 | 0.59 | RHMWM | QNORM | 26.7 | 33.0 | 40.3 | UNK |
| B9 | 2A | 21 | 8 | 0.38 | RHMWM | QNORM | 30.9 | 33.4 | 35.7 | UNK |
| P121 | 2M | 31 | 13 | 0.42 | QNORM | RHMWM | 50.6 | 24.8 | 24.6 | UNK |
| P124 | 2M | 39 | 19 | 0.49 | QNORM | RHMWM | 54.1 | 25.7 | 20.2 | No mutation in exon 28 |
| P125 | 2M | 24 | 6 | 0.25 | QNORM | RHMWM | 45.1 | 21.5 | 33.4 | p.R1374C |
| P214 | 2M | 25 | 11 | 0.44 | QNORM | RHMWM | 59.9 | 18 | 22.1 | p.D1277E_L1278delinsE |
| P216 | 2M | 25 | 6 | 0.24 | QNORM | RHMWM | 67.7 | 11.1 | 21.1 | p.R1315C |
| P251 | 2M | 25 | 4 | 0.16 | QNORM | RHMWM | 60.6 | 13 | 26.4 | p.R1374C |
| P148 | 2N | 80 | 78 | 0.98 | QNORM | RHMWM | 30.4 | 37.9 | 31.7 | p.Q1053H homozygous |
Patient identifier, classification based on the in‐house VW multimer (IHVWM) result, VWF, multimer, densitometry results, and genetic mutations shown if known. Multimer results were either quantitatively normal, QNORM or demonstrated a reduction of high molecular weight multimers (RHMWM). UNK denotes unknown genetic mutation.