FIG 5.

Activity of AX compounds assessed in a mouse model of acute TB. One day after low-dose aerosol M. tuberculosis infection, groups of five mice were treated with vehicle controls (20% TPGS or 20% TPGS with 1% DMSO) or with compounds administered by oral gavage for 10 days daily at the doses indicated (mg/kg). AX compounds were prepared in 20% TPGS, Q203 in 20% TPGS with 1% DMSO, and INH in ddH₂O. Bacterial burden (CFU) was determined from lung homogenates. Data from one experiment are presented as mean ± SD. Statistical analysis was performed using one-way ANOVA, Tukey’s multiple-comparison test (**, P  < 0.01; ****, P  < 0.0001). l.o.d., limit of detection.