Table 1.
Pre‐ and post‐treatment total tremor score in clozapine‐treated PD patients with tremor as an indication
| No. | Age | Medication Before Clozapine and Changes After the Addition of Clozapine | Total (Rest and Action) Tremor Score (UPDRS) Preclozapine Treatmenta | Total tremor Score (UPDRS) Postclozapine Treatment at Last Assessmenta |
|---|---|---|---|---|
| 1 | 52 | Total l‐dopa dose: 2,500 mg/day, sertraline 100 mg/day; no change in medication | 8 | 0 |
| 2 | 62 | Total l‐dopa dose: 875 mg/day, quetiapine 75 mg/day (on stable dose with no effect on tremor), stopped just before initiation of clozapine. Rivastigmine 3 mg/day was added and l‐dopa was decreased to a total l‐dopa dose of 625 mg/day between assessments of tremor score | 15 | 0 |
| 3 | 75 | l‐dopa/benserazide and LD/CD: total l‐dopa 1,750 mg/day in 11 doses amantadine 200 mg/day; no change in medication | 8 | 8 |
| 4 | 56 | Total l‐dopa dose: 1250 mg/day, total pramipexole dose 1.25 mg/day, lorazepam 1 mg at 3 am; no change in medication | 6 | 4 |
| 5 | 74 | Total l‐dopa dose: 1,600 mg/day, total pramipexole dose: 3 mg/day; no change in medication | 4 | 0 |
| 6b | 77 | Total l‐dopa dose: 800 mg/day, trihexyphenidyl 1.5 mg/day, pramipexole 2 mg/day, entacapone 800 mg/day,clonazepam 0.5 mg/day, and quetiapine 25 mg/day; no change in medication | 6 | 5 |
| 7 | 70 | Total l‐dopa dose: 300 mg, pramipexole 1.5 mg/day, and clonazepam 1 mg/day; no change in medication | 24 | 9 |
| 8 (case report) | 75 | Total l‐dopa dose: 1,050 mg/day, pramipexole 0.75 mg/day, and levodopa reduced by 450 mg/day | 6 | 1 |
a
Items 20 and 21 of UPDRS; maximum possible score = 28.
b
Clozapine was stopped 3 months after initiation because of seizures.
CR, controlled release.