Table 1:

Participant Demographics

	CN			EMCI			LMCI			AD
	PSD	NSD	p-value	PSD	NSD	p-value	PSD	NSD	p-value	PSD	NSD	p-value
n (%)	66 (16%)	352	-	118 (38%)	190	-	190 (34%)	371	-	153 (45%)	189	-
Age	73.4±5.3	75.0±5.8	0.04*	72.5±7.6	70.4±7.3	0.018*	73.1±8.2	74.4±7.2	0.057	75.7±7.6	74.4±7.9	0.115
Sex (% male)	51.5	49.7	0.788	56.8	54.7	0.726	63.7	59.8	0.376	58.2	52.9	0.331
Education	16.6±2.3	16.2±2.8	0.314	15.5±2.7	16.2±2.6	0.018*	16.0±2.8	15.8±3.0	0.656	15.5±3.0	15.0±3.0	0.110
APOE Genotype (%)
e3e3	71.2	72.8	0.956	47.9	62.4	0.013*	48.7	44.1	0.472	36.6	31.4	0.418
e3e4	25.8	24.6	-	41.0	33.3	-	40.2	41.9	-	43.1	50.3	-
e4e4	3.0	2.6	-	11.1	4.3	-	11.1	14.1	-	20.3	18.4	-
Sedative/Hypn otic (%)	12.1	6.8	0.137	17.8	10.0	0.048*	10.0	4.0	0.005*	7.2	5.3	0.467
CDRsb	0.0±0.1	0.0±0.1	0.470	1.4±0.8	1.2±0.7	0.024*	1.7+1.0	1.6±0.9	0.485	4.6±1.7	4.3±1.7	0.079
ADAS-11	6.2±3.4	6.0±2.9	0.591	8.1±3.5	7.7±3.5	0.252	11.3±4.6	11.6+4.6	0.420	19.4±7.2	19.4±6.6	0.991
Comorbid Diagnoses (%)
HTN	51.5	44.3	0.281	54.2	44.7	0.105	48.4	48.8	0.935	54.2	47.1	0.188
DM	7.6	7.4	0.957	11.9	10.0	0.607	8.9	7.8	0.644	8.5	10.6	0.516
CAD	3.0	3.1	0.968	3.4	3.2	0.911	4.2	3.8	0.801	3.9	1.6	0.180
GDS	0.9±1.2	0.7+1.1	0.218	2.0±1.6	1.7+1.5	0.038*	2.0±1.5	1.4+1.3	<0.0005*	1.7+1.4	1.6+1.5	0.436

PSD = positive for sleep disturbance symptoms, NSD = negative for sleep disturbance symptoms, CDRsb = Clinical Dementia Rating Scale - Sum of Boxes Score, ADAS-11 = Alzheimer’s Disease Assessment Scale-Cognitive Subscale, HTN = Hypertension, DM = Diabetes CAD = Coronary Artery Disease, GDS = Geriatric Depression Scale, ANOVA for continuous outcomes presented as mean±standard deviation, chi-square test for categorical outcomes,

^*p < .05