Table 3.
Univariable and Multivariable Cox Regression Analyses of Overall Survival in Patients Who Underwent Resection for Pancreatic Adenocarcinoma
| Clinical characteristic | Cohort(n = 127) | Univariable p Value |
|---|---|---|
| Mutation | ||
| Wild-type | 105 (83) | Reference |
| BRCA1/BRCA2 | 22 (17) | 0.036* |
| Hazard ratio | 2.10 | |
| 95% CI | 1.26–3.49 | |
| Multivariable p value | <0.001* | |
| Age, n (%) | ||
| <60 y | 64 (50) | Reference |
| ≥60 y | 63 (50) | 0.395 |
| Sex, n (%) | ||
| Male | 62 (49) | Reference |
| Female | 65 (51) | 0.315 |
| History of diabetes, n (%) | 31 (24) | 0.826 |
| History of smoking, n (%) | 35 (28) | 0.624 |
| Family history of cancer, n (%) | ||
| Any cancer | 78 (67) | 0.410 |
| Pancreatic cancer | 15 (12) | 0.432 |
| Neoadjuvant therapy, n (%) | 22 (17) | 0.313 |
| Adjuvant therapy, n (%) | 99 (80) | <0.001* |
| Hazard ratio | 0.348 | |
| 95% CI | 0.22–0.56 | |
| Multivariable p value | <0.001* | |
| Operative procedure, n (%) | ||
| Pancreaticoduodenectomy | 115 (91) | Reference |
| Distal pancreatectomy | 12 (9) | 0.776 |
| Positive nodal metastases, n (%) | 90 (71) | 0.081* |
| Hazard ratio | 1.44 | |
| 95% CI | 0.91–2.29 | |
| Multivariable p value | 0.121 | |
| Grade, n (%) | ||
| 1 | 7 (6) | Reference |
| 2 | 61 (48) | 0.821 |
| 3 | 57 (45) | 0.601 |
| T-stage, n (%) | ||
| T1 | 10 (7) | Reference |
| T2 | 36 (28) | 0.822 |
| T3 | 79 (63) | 0.370 |
| T4 | 2 (2) | 0.350 |
| Perivascular invasion, n (%) | ||
| No | 55 (43) | Reference |
| Yes | 62 (49) | 0.194 |
| Perineural invasion, n (%) | ||
| No | 18 (14) | Reference |
| Yes | 109 (86) | 0.891 |
| Resection margin, n (%) | ||
| R0 | 92 (72) | Reference |
| R1 | 35 (28) | 0.032* |
*
Statistically significant.