eTable 1.

Mutation Detail of BRCA-Mutated Patients

Patient#	Age, y	Gene	Chromosome position	Amino acid change	Nucleotide change	Function
1	66	BRCA2	13:32911298–9	p.K936Kfs	c.2808_2811delACAA	Frameshift*
2	60	BRCA2	13:32911298–9	p.K936Kfs	c.2808_2811delACAA	Frameshift*
3	83	BRCA2	13:32911419	p.S976Sfs	c.2928delC	Frameshift*
4	63	BRCA2	13:32914401	p.S1970X	c.5909C>AC	Nonsense*
5	62	BRCA2	13:32914438	p.S1982Rfs	c.5946delT	Frameshift*
6	61	BRCA2	13:32914438	p.S1982Rfs	c.5946delT	Frameshift*
7	57	BRCA2	13:32914438	p.S1982Rfs	c.5946delT	Frameshift*
8	60	BRCA2	13:32914438	p.S1982Rfs	c.5946delT	Frameshift*
9	59	BRCA2	13:32932067	Splice	c.7805+1G>A	Noncoding*
10	65	BRCA2	13:32972626	p.K3326X	c.9976A>T	Nonsense*
11	65	BRCA2	13:32972626	p.K3326X	c.9976A>T	Nonsense*
12	76	BRCA2	13:32893421	p.Q92R	c.275A>G	Missense†
13	68	BRCA2	13:32912190	p.A1233V	c.3698C>T	Missense†
14	58	BRCA2	13:32911703	p.H1071Y	c.3211C>T	Missense†
15	66	BRCA2	13:32911794	p.H1101R	c.3302A>G	Missense†
16	54	BRCA2	13:32912586	p.C1365Y	c.4094G>A	Missense†
17	56	BRCA2	13:32915133	p.T2214I	c.6641C>T	Missense†
18	49	BRCA2	13:32931943	p.Q2561R	c.7682A>G	Missense†
19	50	BRCA1	17:41243887	p.E1221X	c.3661C>A	Nonsense*
20	58	BRCA1	17:41276034	fs	c.70_80delCAGATGGGACA	Frameshift*
21	61	BRCA1	17:41245975	p.V525I	c.1573C>T	Missense†
22	57	BRCA1	17:41245975	p.V525I	c.1573C>T	Missense†

^*Known pathogenic variant.

^†Variant with unknown significance (VUS).