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Prevention of erastin-induced ferroptosis by GPX4 activator compound 102 in HT-1080 cells. (A) Compound 102 prevented cell death dose-dependently with a lethal concentration of erastin (10 μM). (B) Death-suppression by compound 102 with increasing erastin (Era) concentrations. Data shown represent the mean ± standard error of mean (SEM; n = 5). The statistical significance was determined using a two-tailed t-test, ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001.
