Table 3.
Assessment of proportional hazard assumptions for Cox models.
| Overall survival |
Disease specific survival |
|||||||||||
| METABRIC Discovery |
METABRIC Validation |
METABRIC Discovery |
METABRIC Validation |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Variable in model | rho† | chisq• | P§ | rho | chisq | P | rho | chisq | P | rho† | chisq | P |
| CNA burden | -0.06 | 1.43 | 0.23 | 0.04 | 0.73 | 0.39 | <-0.01 | <0.01 | 0.99 | 0.06 | 0.74 | 0.39 |
| CNA burden | -0.09 | 3.14 | 0.08 | 0.03 | 0.29 | 0.59 | -0.02 | 0.13 | 0.72 | 0.05 | 0.5 | 0.48 |
| Age at diagnosis | 0.21 | 28.75 | <0.01 | 0.18 | 19.82 | <0.01 | 0.21 | 15.37 | <0.01 | 0.08 | 2.07 | 0.15 |
| Global∗ | - | 30.44 | <0.01 | - | 20.55 | <0.01 | - | 15.37 | <0.01 | – | 31.7 | <0.01 |
| CNA burden | -0.05 | 0.77 | 0.38 | 0.04 | 0.73 | 0.39 | 0.02 | 0.05 | 0.82 | 0.04 | 0.42 | 0.52 |
| PAM50 Subtypes | ||||||||||||
| Normal | -0.15 | 9.59 | <0.01 | -0.03 | 0.45 | 0.5 | -0.12 | 3.48 | 0.06 | 0.12 | 3.28 | 0.07 |
| LumA | Ref.♢ | – | – | Ref. | – | – | Ref. | – | – | Ref. | – | – |
| LumB | -0.13 | 7.38 | 0.01 | <-0.01 | 0.03 | 0.87 | -0.11 | 3.27 | 0.07 | 0.13 | 4.36 | 0.04 |
| Her2 | -0.23 | 22.54 | <0.01 | -0.11 | 5.8 | 0.02 | -0.21 | 11.93 | <0.01 | -0.02 | 0.11 | 0.74 |
| Basal | -0.32 | 43.53 | <0.01 | -0.25 | 28.23 | <0.01 | -0.4 | 41.01 | 0.15 | -0.12 | 3.28 | 0.07 |
| Global | – | 59.39 | <0.01 | – | 39.75 | <0.01 | – | 45.88 | <0.01 | – | 31.7 | <0.01 |
| CNA burden | -0.07 | 1.63 | 0.2 | 0.04 | 0.8 | 0.37 | 0.01 | 0.02 | 0.9 | 0.04 | 0.42 | 0.52 |
| Age at diagnosis | 0.15 | 13.51 | <0.01 | 0.12 | 8.27 | <0.01 | 0.11 | 3.97 | 0.04 | -0.004 | 0.006 | 0.94 |
| PAM50 Subtypes | ||||||||||||
| Normal | -0.13 | 6.7 | <0.01 | 0.003 | 0.004 | 0.95 | -0.11 | 2.76 | 0.1 | 0.12 | 3.18 | 0.07 |
| LumA | Ref. | – | – | Ref. | – | – | Ref. | – | – | Ref. | – | – |
| LumB | -0.13 | 7.46 | <0.01 | -0.02 | 0.22 | 0.64 | -0.12 | 3.77 | 0.05 | 0.13 | 4.38 | 0.04 |
| Her2 | -0.21 | 19.04 | <0.01 | -0.13 | 6.9 | <0.01 | -0.2 | 10.55 | <0.01 | -0.02 | 0.11 | 0.73 |
| Basal | -0.29 | 34.1 | <0.01 | -0.23 | 20.66 | <0.01 | -0.36 | 32.18 | <0.01 | -0.12 | 3.17 | 0.07 |
| Global | – | 75.15 | <0.01 | – | 50.45 | <0.01 | – | 49.98 | <0.01 | – | 31.7 | <0.01 |
†Pearson Correlation Coefficients between survival time and Scholenfeld Residuals. •Chi-square statistics results. §p-value of the null hypothesis that the proportional hazard assumption is valid for a variable. ∗Assessment results when taking all variables of a model into consideration. ♢Reference category. The baseline category of PAM50 subtype in multivariable cox model.