Table 2.
Estimated relative and absolute potencies (IU/mg) of pairs of tuberculin batches with 95% CI's in six guinea pig trials.
Trial | Batch pair | N | Rel. pot. (95% CI) | Potency (95% CI) |
---|---|---|---|---|
T1 | RS, BIS | 48 | 1.230 (0.757–2.025) | 39,975 (24,603–65,813)* |
A, BIS | 48 | 1.233 (0.828–1.853) | 40,073 (26,910–62,223)* | |
A, RS | 48 | 1.095 (0.739–1.627) | 37,997 (25,643–56,457)** | |
T2 | RS, BIS | 48 | Non-parallel | – |
A, BIS | 48 | Significant curvature | – | |
A, RS | 48 | Non-parallel | – | |
T3 | RS, BIS | 45 | Non-parallel | – |
A, BIS | 45 | 0.782 (0.444–1.338) | 25,415 (14,430–43,485)* | |
A, RS | 46 | 1.081 (0.760–1.542) | 35,133 (24,700–50,115)** | |
T4 | RS, BIS | 41 | 1.132 (0.678–1.893) | 39,280 (23,527–65,687)* |
C, BIS | 43 | 1.103 (0.710–1.689) | 35,848 (23,075–54,893)* | |
C, RS | 44 | 0.957 (0.639–1.417) | 33,208 (22,173–49,170)** | |
T5 | RS, BIS | 39 | 0.954 (0.585–1.565) | 31,005 (19,013–50,863)* |
D, BIS | 42 | 1.181 (0.794–1.756) | 38,383 (25,805–57,070)* | |
D, RS | 41 | 1.189 (0.766–1.827) | 41,258 (26,580–63,397)** | |
T6 | RS, BIS | 41 | 1.131 (0.745–1.761) | 36,785 (24,213–57,233)* |
B, BIS | 42 | 0.975 (0.656–1.465) | 31,688 (21,320–47,613)* | |
B, RS | 39 | 0.852 (0.559–1.285) | 29,564 (19,397–44,590)** | |
T1, T4, T5, T6 | RS, BIS | 169 | 1.115 (0.871–1.432) | 36,238 (28,308–46,540)* |
Relative potencies multiplied by 32,500 (potency assigned to BIS).
Relative potencies multiplied by 34,700 (potency assigned to RS when calibrated against bis in cattle).