Table 1.
Demographic characteristics of the 40 obese pediatric participants in the pharmacokinetic analysis and model development.
| Variable | Median (range) or N (%) | ||
|---|---|---|---|
| Age 6–11 yrs | Age 12–17 yrs | All | |
| N | 19 | 21 | 40 |
| Age (years) | 10 (6–11) | 14 (12–17) | 12 (6–17) |
| Total body weight (kg) | 54.5 (32.4–123.4) | 97.5 (67.2–131.6) | 77.6 (32.4–131.6) |
| Lean body weight (kg) | 35.0 (21.0–60.2) | 55.5 (43.1–81.4) | 48.7 (21.0–81.4) |
| Body mass index (kg/m2) | 25.3 (22.1–42.0) | 36.5 (26.8–41.5) | 29.9 (22.1–42.0) |
| Waist:hip ratio | 0.90 (0.81–1.01) | 0.88 (0.77–1.09) | 0.90 (0.77–1.09) |
| Resting energy expenditure (kcal) | 1580 (750–2090) | 2110 (1420–2910) | 1810 (750–2910) |
| Female | 12 (63) | 10 (48) | 22 (55) |
| Race | |||
| White | 8 (42) | 12 (57) | 20 (50) |
| Black or African American | 7 (37) | 5 (24) | 12 (30) |
| Asian | 1 (5) | 0 (0) | 1 (2.5) |
| Other | 3 (16) | 4 (19) | 7 (17.5) |
| Obesity status | |||
| Obese | 15 (79) | 13 (62) | 28 (70) |
| Morbidly obese | 4 (21) | 8 (38) | 12 (30) |
| CYP2C19 genotype | |||
| Poor metabolizer | 1 (5) | 0 (0) | 1 (3) |
| Intermediate metabolizer | 9 (47) | 9 (43) | 18 (45) |
| Extensive metabolizer | 9 (47) | 12 (57) | 21 (52) |
Data are median (range) for continuous variables or N (%) for categorical variables.