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. Author manuscript; available in PMC: 2018 Oct 10.
Published in final edited form as: Cell Rep. 2018 Jul 24;24(4):973–986.e8. doi: 10.1016/j.celrep.2018.06.100

Figure 1. Chmp1a Is Essential for Brain Development in Mice.

Figure 1.

(A) P0 Chmp1a null pups are smaller than litter-mate controls.

(B) P0 Chmp1a null pups have smaller brains than controls. Note smaller olfactory bulbs and shorter anterior-posterior (A-P) length of the cortex.

(C) Body mass is reduced in Chmp1a null embryos. P0: control, n = 19; Chmp1a null, n = 3.

(D) Brain mass is reduced in Chmp1a null embryos. E14.5: control, n = 10; Chmp1a null, n = 5. E17.5: control, n = 23; Chmp1a null, n = 4. E18.5: control, n = 20; Chmp1a null, n = 3. P0: control, n = 9; Chmp1a null, n = 3.

(E) Cortical plate is 13% thinner in Chmp1a null embryos at E18.5. Control, n = 11; Chmp1a null, n = 5.

(F) Striatum area is reduced by 25% at E18.5 in Chmp1a null embryos compared to controls. Control, n = 8; Chmp1a null, n = 3.

(G) P0 midline section shows cerebellar hypoplasia (21% reduction of perimeter) in Chmp1a null pups compared to control littermates. Control, n = 7; Chmp1a null, n = 4.

(H) Quantification of (E)–(G).

Two-tailed t test, *p < 0.05, **p < 0.01, ***p < 0.001. Error bars are SEM.