Table 2.

Key eligibility criteria of PROSPER RCC (EA8143)

Key Inclusion Criteria	Key Exclusion Criteria
•Clinical T2 or any node positive RCC	•No active or suspected autoimmune disorders
•No evidence of metastatic disease (M0)	- Exceptions: vitiligo, diabetes type 1, hypothyroid on stable hormone
•Clear cell or non-clear cell histology	replacement, psoriasis, conditions not expected to recur
- Non-clear cell will be limited to 15%	•No disorders requiring steroids >10 mg prednisone or its equivalent daily
•Planned for nephrectomy (partial or radical)
•ECOG performance status 0 or 1	•Limitations on prior cancers
•Adequate end organ function—hematologic, hepatic, renal, neurologic

^*See www.clincialtrials.gov for full listing.