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. 2017 Sep 13;1:PO.17.00036. doi: 10.1200/PO.17.00036

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© 2017 by American Society of Clinical Oncology

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Fig 3. — Clinical decisions made for a subset of patients annotated with actionable variant calls. (A) Patients annotated in 2015 through clinician-initiated requests and for treatment planning conferences. The fraction of patients represented by the highest variant call (yellow column) and the corresponding fraction of patients with that call enrolled in a trial (gray column). (B) Accrual in genomically matched clinical trials on the basis of variant actionability (P < .001). (C) A subset of patients annotated in 2015 through a clinician-initiated request and for whom a survey was returned. The fraction of patients represented by the highest variant call (yellow column) and the corresponding fraction of patients with that call enrolled in a trial (gray column). Trial enrollment varied significantly by variant actionability (P < .001).