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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: Neurobiol Aging. 2018 Aug 1;71:161–170. doi: 10.1016/j.neurobiolaging.2018.07.018

Fig. 1. Schematic of white matter degeneration.

Fig. 1.

White matter degeneration leads to increased interstitial space at older ages. Intracellular water diffusion is restricted, while nearby extracellular water is hindered by myelin layers and other tissue components (purple). In the deep interstitial spaces, water is far enough from boundaries such that it can diffuse freely within a short diffusion time (blue).