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Histopathologic characteristics of APAs harboring somatic mutations in ATP1A1, ATP2B3, and CACNA1D. (A‒C) APA with ATP1A1 p.E960_L964delinsAV mutation. (D‒F) APA with ATP2B3 p.V422_L425delinsIT mutation. (G‒I) APA with CACNA1D p.V259G mutation (case 23). (J‒L) APA with p.V259G mutation (case 55). (A, D, G, and J) Hematoxylin and eosin (H&E) staining. (B, E, H, and K) CYP11B2 IHC. (C, F, I, and L) CYP17A1 IHC. Scale bar: 100 µm.
