Figure 3.

Radiologic responses per Response Evaluation Criteria in Solid Tumors, version 1.1, for all nine patients treated with RAI. (A) Best overall response while receiving TTx before RAI therapy. (B) Best overall response after RAI therapy while off TTx. (C) Side-by-side view of additional response achieved after RAI therapy. (D) I¹³¹ single-photon emission computed tomography revealed an RAI-avid lymph node in the right hilum (red arrow) in a patient with RAS mutation patient while receiving TTx. Serial CT chest scans demonstrate right hilar adenopathy PR after 208 mCi of I¹³¹ (decrease from 3.0 × 2.4 cm to 1.7 × 1.2 cm). (E) I¹³¹ single-photon emission computed tomography revealed multiple pulmonary RAI-avid nodules (red arrowhead) in a patient with BRAF mutation while receiving TTx. Serial CT chest scans demonstrated PR after 204 mCi of I¹³¹ with almost complete resolution of pulmonary nodule. *Patients who received targeted therapy in an attempt to rensensitize their tumors to RAI. ^The patient who was empirically treated with RAI despite no uptake on scan.