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Measurement of Lipid Peroxidation and DNA Oxidative Damage Markers in Urine Samples
| Hyperthyroid Untreated GD (Group A) (n = 54) | Toxic Nodular Goiter (Group B) (n = 5) | Euthyroid Healthy Control Subjects (Group C) (n = 42) |
P Value
|
||
|---|---|---|---|---|---|
| A vs B | A vs C | ||||
| Lipid peroxidation | |||||
| MDA, µM MDA/g creatinine | 7.4 ± 0.6 | 3.0 ± 0.4 | 3.2 ± 0.2 | 0.001 | 0.01 |
| 8-isoprostane, pg/mL | 959 ± 121 | 450 ± 19 | 419 ± 16 | 0.04 | 0.02 |
| DNA oxidative damage | |||||
| 8-OH-dG, ng/mL | 110 ± 16 | 41 ± 13 | 37 ± 10 | 0.04 | 0.03 |
Values are mean ± SEM.
