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. 2018 Aug 2;103(10):3757–3766. doi: 10.1210/jc.2018-00780

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Figure 3. — (A) Example of the mediation analysis of the sphingomyelin effect on residual SLEEP accounted for by AEA. Residual SLEEP was calculated after adjustment for FFM via linear regression analysis. Path coefficients (±SE) are shown for the associations between SM18:1/23:1 (independent variable) and AEA (mediator), SM18:1/23:1 and SLEEP (dependent variable), and AEA and residual SLEEP, and were derived by linear regression analysis. The endocannabinoid-specific effect of SM18:1/23:1 on residual SLEEP exerted by AEA was calculated by multiplication of the path coefficients for the associations between SM18:1/23:1 and AEA and between AEA and residual SLEEP, respectively. The Sobel test was used to test the significance of the endocannabinoid-specific effect. Mediation analysis was performed in 29 subjects with complete SLEEP, endocannabinoid, and sphingolipid measurements. (B) Percentage of the total effect of SM18:1/23:1 on residual SLEEP as accounted by the endocannabinoid-specific (i.e., via AEA) vs direct (i.e., SM18:1/23:1 only, independent of AEA) effect.