Table 3. Univariate and multivariate analysis of the effects of CTC and clinicopathological characteristics on disease-free survival in patients with cervical cancer.
| Clinicopathological characteristics | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Age (≥ 45 years vs. < 45 years) | 0.941 (0.466–1.901) | 0.865 | ||
| Tumor size (≥ 4 cm vs. < 4 cm) | 1.108 (0.617–1.991) | 0.731 | ||
| Histological types (Adenosqua vs. Adeno vs. Squa) | 1.527 (0.740–3.152) | 0.252 | ||
| FIGO stage (IV vs. III vs. II) | 2.202 (1.458–3.326) | 0.000 | 1.671 (1.109–2.517) | 0.014 |
| SCC-Ag (≥5 ng/ml vs. < 5 ng/ml) | 3.125 (1.581–6.175) | 0.001 | 2.338 (1.162–4.705) | 0.017 |
| Parametrial extension (Yes vs. No) | 1.042 (0.574–1.893) | 0.892 | ||
| CTC status (Positive vs. Negative) | 3.354 (1.850–6.080) | 0.000 | 2.425 (1.313–4.477) | 0.005 |
NOTE: CTC, circulating tumor cells; Adenosqua, Adenosquamous carcinoma; Adeno, Adenocarcinoma; Squa, Squamous cell carcinoma; FIGO, International Federation of Gynecology and Obstetrics; SCC-Ag, Squamous cell carcinoma antigen; HR, hazard ratio; CI, confidence interval. The bold type represents P values smaller than 0.05.