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. 2018 Oct 10;13(10):e0205433. doi: 10.1371/journal.pone.0205433

Table 3. Quantitative outcomes of tuberculosis patient support interventions in low incidence countries described in studies not allowing for comparisons to a control group.

Source Intervention Target group* N Outcome N outcome
Charokopos et al., 2013 [49], Greece Modified DOT Newly diagnosed TB patients 54 Treatment completion 11 (85%)
Craig et al., 2008 [43], UK TB link worker Adult TB/LTBI patients referred on the basis of social need to TBLW 90 Treatment completion 70 (78%)
Escudero et al., 2006 [40], Spain In-patient DOT HIV-negative MDR-TB patients 25 Treatment completion 21 (84%)
Ferrer et al., 2010 [41], USA DOT by social worker MDR-TB patients 46 Treatment completion 30 (65%)
Garfein et al., 2015 [44], USA VOT via uploading videos via a smart phone app + daily text message reminders Adult newly diagnosed DS TB patients treated under VOT 41
Treatment adherence [average doses missed] 2.7±7
Treatment adherence [observed doses/ expected doses] 93%
Jit et al., 2011 [51], UK Find and Treat Service Hard to reach individuals with active PTB 188 Treatment completion# 61%
Luzzati et al., 2011 [45], Italy In-patient DOT Adult patients admitted to referral TB Centre for high risk 122 Treatment adherence [not defined] 96%
Mejuto et al., 2010 [38], Spain DOT at various locations TB patients who received DOTS treatment 253 Treatment completion 213 (82%)
Pursnani et al., 2014 [50], USA Out-patient DOT Patients on out-patient DOT 70 Treatment completion 62 (89%)

*descriptions of the target groups can be found in S2 Appendix

#Based on modelling data

DOT: Directly Observed Treatment, N: number, PTB: Pulmonary TB, TB: Tuberculosis, VOT: Video observed treatment