Table 1.

Study Overview

Study	Sample	Modality	Treatment	Dosage	Administration	Classification	Design	Blinding	Measure	Stimulus
Aslaksen et al. (2015)	93	Pain	Lidocaine	3.0 g	Topical	SCBa	BPDb	−	Self-report	Thermode
Atlas et al. (2012)	14	Pain	Remifentanil	0.04 μg/kg/min	Intravenous	Opioid	BOHDc	−	Self-report	Thermode
Berna et al. (2017)	100	Pain	Diclofenac	100 mg	Oral (pill)	NSAIDd	BAPDe	+	Self-report	Thermode
Butcher and Carmody (2012)	20	Pain	Ibuprofen	800 mg	Oral (pill)	NSAID	BPD	+	Multiple outcomes	Electrical
Kam-Hansen et al. (2014)	66	Migraine	Maxalt	10 mg	Oral (pill)	Triptan	BPD	NRf	Self-report	Migraine
Lund et al. (2014)	46	Pain	Lidocaine	0.1 ml	Intramuscular	SCB	BOHD	+	Self-report	Hypertonic saline
Schenk et al. (2014)	32	Pain	Lidocaine/prilocaine	NR	Topical	SCB	BPD	+	Self-report	Thermode

^aSodium channel blocker.

^bBalanced placebo design.

^cBalanced open-hidden design

^dNonsteroidal anti-inflammatory drug.

^eBalanced active placebo design.

^fNot reported