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The in vivo analysis of PD-induced BBB opening for rhodamine-dextran. (a) The timeline of the experiment. (b) and (c) are the same area imaged by 2PLSM before and after PD. (d) and (e) are the magnified images corresponding to the areas boxed in (b) and (c), respectively. (f) The bar graph of the average signal intensity inside (1-6) and outside (1’-6’) vessels.
