Table 1. PD-induced BBB opening for the EBd albumin complex.

Groups	Content of Evans Blue in the brain (µg/g tissue)
Untreated mice	0.685 ± 0.012
5-ALA	0.650 ± 0.011
Laser 10, 20, 30, 40 J/cm2	0.708 ± 0.007	0.673 ± 0.003	0.700 ± 0.006	0.801 ± 0.011
PD (5-ALA + laser) without optical clearing skull window
10, 20, 30, 40 J/cm2	0.741 ± 0.017	0.687 ± 0.013	0.807 ± 0.015	0.796 ± 0.010
PD (5-ALA + laser) with optical clearing skull window
10, 20, 30, 40 J/cm2	7.618 ± 0.496 ***	13.863 ± 0.712 ***	18.017 ± 1.171 ***	18.295 ± 1.466 ***

^***-p<0.001 the comparison between untreated mice and mice underwent PD through optical clearing skull window, n = 6 in each group and sub-group.