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. Author manuscript; available in PMC: 2018 Oct 10.
Published in final edited form as: Biochem Pharmacol. 2017 Apr 19;137:93–106. doi: 10.1016/j.bcp.2017.04.017

Figure 1.

Figure 1.

miRNAs identified through a functional genomics library screen that reduce UGT1A 3’-UTR luciferase reporter (pMIR-UGT1A) activity by at least 30% without affecting activity of the empty vector (pMIR). Shown are relative luciferase activities (firefly/Renilla ratio normalized to the pMIR control ratio) of HEK293 cells co-transfected with the pMIR-UGT1A or pMIR and with each miRNA mimic, a positive control (siUGT1A: short interfering RNA directed against the UGT1A 3’-UTR) or the mimic negative control. Bars represent mean ± one S.D. from three independent experiments performed in quadruplicate. * p < 0.05, ** p < 0.01, *** p < 0.001.