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. Author manuscript; available in PMC: 2018 Oct 10.
Published in final edited form as: Biochem Pharmacol. 2017 Apr 19;137:93–106. doi: 10.1016/j.bcp.2017.04.017

Figure 8.

Figure 8.

Locations of known miRNA response elements (MREs) in the reference (top) and variant (bottom) UGT1A 3’-UTR. Indicated are the positions (from nucleotides +1 to +740 downstream of the UGT1A stop codon) of the six MREs validated in this study (red triangles) and the MRE for miR-491–3p, which had been reported previously [16]. Also indicated are the positions of the three linked SNPs (rs10929303, rs1042640, and rs8330) that comprise the variant UGT1A 3’-UTR allele. The rs10929303 SNP was found to substantially increased binding of miR-21–3p to the variant allele, while the rs8330 SNP abolished binding of miR-1286 to the variant 3’-UTR.