Table 1.
NSRRC Swine Availability
| Strain Name | Modification(s) | Gene(s) | Application(s) |
|---|---|---|---|
| Truline® Hampshire | none | wildtype | background for genetic modification |
| Truline® Duroc | none | wildtype | background for genetic modification |
| Truline® Landrace | none | wildtype | background for genetic modification |
| Truline® Large White | none | wildtype | background for genetic modification |
| Minnesota Mini | none | wildtype | immune system ontogeny and regulation, xenotransplantation, xenoimmunotherapy of cancer |
| Ossabaw | none | wildtype | background for genetic modification, obesity, diabetes, cardiovascular, Polycystic ovarian syndrome |
| GGTA1KO/hDAF | transgenic targeted knock-out | α-1,3-galactosyltransferase knockout; human decay-accelerating factor | xenotransplantation research |
| GFP NT5 | transgenic | enhanced green fluorescent protein | cell tracking |
| FAT-1 | transgenic | express a humanized Caenorhabditis elegans gene, fat-1, encoding an n-3 fatty acid desaturase | research in the areas of reproduction, cardiovascular, immune system, depression and cancer |
| Yucatan | none | Wildtype | small porcine model as background for genetic modification |
| NIH Mini g/g | none | MHC SLA g/g | research in the areas of immune system, and xenotransplantation |
| NIH Mini c/c | none | MHC SLA c/c | research in the areas of immune system, and xenotransplantation |
| NIH Mini a/a | none | MHC SLA a/a | research in the areas of immune system, and xenotransplantation |
| GFP NT92 | transgenic | enhanced green fluorescent protein | cell tracking |
| Rhodopsin | transgenic | rhodopsin P23H substitution | retinitis pigmentosa research |
| FVIII | tri-transgenic | human coagulation factor VIII; human alpha-antitrypsin; propeptide cleavage enzyme (PACE) | hemophilia research |
| FIX | tri-transgenic | human coagulation factor IX; human alpha-antitrypsin; von Willebrand factor | hemophilia research |
| GFP NT92-Yucatan | transgenic | enhanced green fluorescent protein | cell tracking |
| Tie2-eNOS | transgenic | endothelial nitrate oxide synthase | cardiovascular, exercise physiology |
| Tie2-Catalase | transgenic | human catalase | cardiovascular, exercise physiology |
| PSMA1-GFP | transgenic | GFP-Proteasome Fusion Protein | proteasome research |
| Multi-Xeno | transgenic | α-1,3-galactosyltransferase knockout; human decay-accelerating factor (CD55); CD39; CD59 and thrombomodulin | xenotransplantation |
| NLS-CAG-eGFP | transgenic | nuclear localized signal-CAG-enhanced green fluorescent protein | cell tracking |
| CAG-Tomato | transgenic | CAG-Tomato | cell tracking |
| AFP-CD | transgenic | alpha fetoprotein promoter driving cytosine deaminase | liver research |
| ALB-TK | transgenic | albumin promoter driving thymidine kinase | liver research |