Skip to main content
. Author manuscript; available in PMC: 2019 Oct 15.
Published in final edited form as: J Immunol. 2018 Sep 12;201(8):2354–2368. doi: 10.4049/jimmunol.1800671

FIGURE 5.

FIGURE 5.

IL-13 induction and STAT6 activation are linked to chronic lung disease after IAV infection. (A) Time course of body weight change in wild-type (WT), Il13–/–, and Stat6–/– mice on the indicated days after infection with IAV (2 pfu) or IAV-UV. (B) Time course for lung levels of IAV-PA RNA in the same mouse strains after infection with IAV (2 pfu). (C) Lung levels of Il13, Muc5ac, and Clca1 mRNA in the same mouse strains at 21 d after infection with IAV (2 pfu) or IA-UV. (D) PAS-hematoxylin staining of lung sections from WT and Il13–/–mice at 21 d after infection with IAV (2 pfu) or IAV-UV. Bar=1 mm. (E) Quantitation of PAS-positive areas in images in (D). (F) Quantitation of PAS+ area for conditions in (D). (F) Levels of IAV-PA RNA and Muc5ac mRNA in uninvolved or involved sections of lung from WT and Il13–/– mice at 21 d after infection with IAV or IAV-UV. For (A-C) and (E-F), values are representative of 3 separate experiments (n≥8 mice per condition in each experiment). * indicates p<0.05; ns=nonsignificant.