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. Author manuscript; available in PMC: 2019 Oct 15.
Published in final edited form as: J Immunol. 2018 Sep 12;201(8):2354–2368. doi: 10.4049/jimmunol.1800671

FIGURE 6.

FIGURE 6.

Reciprocal IL-17a induction after IL-13 blockade is not linked to chronic lung disease after IAV infection. (A) Lung levels of Il17a and Il17f mRNA in WT, Il13–/–, Il17a–/–, and Il13–/––Il17a–/– mice at 21 d after infection with IAV (2 pfu) or IA-UV. (B) Time course of body weight change in the same mouse strains as (A) after infection with IAV (2 pfu) or IAV-UV. (C) Time course for lung levels of IAV-PA RNA for conditions in (B). (D) Lung levels of Il13, Muc5ac, and Clca1 mRNA in same mouse strains as (A) at 21 d after infection with IAV (2 pfu) or IAV-UV. (E) Levels of indicated immune cells in BAL fluid for conditions in (D). (F) Levels of airway reactivity using response of respiratory system resistance (RRS) to inhaled methacholine (MCh) and for baseline RRS for conditions in (D). For (A-F), values are representative of 3 separate experiments (n=5–8 mice per condition in each experiment). For (A-E), * indicates p<0.05; for (F), * indicates p<0.05 versus IAV-UV and ** indicates p<0.05 versus corresponding IAV-UV and IAV conditions.