Skip to main content
. 2018 Oct 4;23(4):557–571.e8. doi: 10.1016/j.stem.2018.09.008

Figure 4.

Figure 4

Distinct TF-Target Regulatory Elements Are Stage- and Lineage-Specifically Activated during Astrogliogenesis versus Neurogenesis

(A–C) Heatmaps depicting the enrichment of H3K27ac and H3K4me1 during stages of either astroglial or neuronal differentiation at the genomic locations of the Nfia (A), Atf3 (B), and Lhx2 (C) motifs within the scope of unique eA, in the cases of Nfia and Atf3, and eN, in the case of the Lhx2, H3K27ac peaks, including the promoters.

(D–I) Expression of the genes nearest to and within 50 kb of the sites depicted in (A)–(C) in astroglial (D, F, and H) and neuronal (E, G, and I) differentiation (log2-normalized read counts).

(J and K) Same as (A)–(C) except for the Runx2 and Brn1 motif sites within the scope of the lA and lN H3K27ac unique peaks, respectively, including the promoter.

(L–O) Same as (D)–(I) except for the Runx2 and Brn1 motif sites within the scope of the lA and lN unique H3K27ac peaks, respectively, including the promoter.