Table 2. Univariate and multivariate logistic analyses of decreased GFR (< 60 mL/min/1.73 m2) with subgroup analysis by sex.
| Subjects | Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|---|
| OR | 95% CI | P value | OR | 95% CI | P value | ||
| Total subjects | |||||||
| Age, ≥ 50 yr | 6.14 | 4.42–8.53 | < 0.001 | 5.49 | 3.65–8.26 | < 0.001 | |
| Sex, male | 1.03 | 0.92–1.17 | 0.591 | ||||
| BMI, ≥ 25 kg/m2 | 1.37 | 1.21–1.55 | < 0.001 | 1.31 | 1.13–1.52 | < 0.001 | |
| Total protein, ≥ 6.4 g/dL | 0.59 | 0.40–0.88 | 0.009 | 0.68 | 0.44–1.07 | 0.095 | |
| Albumin, ≥ 3.5 g/dL | 0.12 | 0.06–0.24 | < 0.001 | 0.23 | 0.09–0.56 | 0.001 | |
| Bilirubin, ≥ 1.2 mg/dL | 0.75 | 0.64–0.88 | < 0.001 | 0.81 | 0.67–0.98 | 0.029 | |
| HbA1c, ≥ 6.5% | 2.27 | 1.87–2.75 | < 0.001 | 1.89 | 1.53–2.33 | < 0.001 | |
| Anemia | 2.16 | 1.74–2.68 | < 0.001 | 2.28 | 1.75–2.98 | < 0.001 | |
| Platelet count, ≥ 150 × 109/L | 0.63 | 0.50–0.80 | < 0.001 | 0.83 | 0.62–1.12 | 0.215 | |
| Cholesterol, ≥ 200 mg/dL | 0.99 | 0.88–1.11 | 0.851 | ||||
| HBsAg positivity | 1.28 | 1.12–1.47 | < 0.001 | 1.23 | 1.04–1.45 | 0.015 | |
| Male subjects | |||||||
| Age, ≥ 50 yr | 6.56 | 4.25–10.13 | < 0.001 | 4.99 | 3.03–8.22 | < 0.001 | |
| BMI, ≥ 25 kg/m2 | 1.16 | 0.99–1.34 | 0.057 | ||||
| Total protein, ≥ 6.4 g/dL | 0.45 | 0.29–0.69 | < 0.001 | 0.62 | 0.37–1.02 | 0.059 | |
| Albumin, ≥ 3.5 g/dL | 0.08 | 0.04–0.16 | < 0.001 | 0.24 | 0.09–0.66 | 0.005 | |
| Bilirubin, ≥ 1.2 mg/dL | 0.71 | 0.60–0.85 | < 0.001 | 0.78 | 0.63–0.95 | 0.015 | |
| HbA1c, ≥ 6.5% | 2.24 | 1.80–2.80 | < 0.001 | 1.72 | 1.36–2.17 | < 0.001 | |
| Anemia | 12.25 | 8.58–17.47 | < 0.001 | 7.05 | 5.19–9.57 | < 0.001 | |
| Platelet count, ≥ 150 × 109/L | 0.61 | 0.47–0.80 | < 0.001 | 0.79 | 0.57–1.09 | 0.149 | |
| Cholesterol, ≥ 200 mg/dL | 0.93 | 0.80–1.08 | 0.328 | ||||
| HBsAg positivity | 1.39 | 1.17–1.63 | < 0.001 | 1.39 | 1.14–1.69 | 0.001 | |
| Female subjects | |||||||
| Age, ≥ 50 yr | 5.58 | 3.38–9.22 | < 0.001 | 5.98 | 3.07–11.66 | < 0.001 | |
| BMI, ≥ 25 kg/m2 | 2.03 | 1.64–2.52 | < 0.001 | 1.74 | 1.35–2.24 | < 0.001 | |
| Total protein, ≥ 6.4 g/dL | 1.43 | 0.53–3.86 | 0.482 | ||||
| Albumin, ≥ 3.5 g/dL | 1.00 | 0.99–1.01 | 0.999 | ||||
| Bilirubin, ≥ 1.2 mg/dL | 0.85 | 0.60–1.19 | 0.342 | ||||
| HbA1c, ≥ 6.5% | 2.37 | 1.59–3.53 | < 0.001 | 1.89 | 1.25–2.87 | 0.003 | |
| Anemia | 1.29 | 0.96–1.73 | 0.097 | ||||
| Platelet count, ≥ 150 × 109/L | 0.71 | 0.44–1.13 | 0.145 | ||||
| Cholesterol, ≥ 200 mg/dL | 1.11 | 0.91–1.36 | 0.304 | ||||
| HBsAg positivity | 1.10 | 0.86–1.40 | 0.456 | ||||
GFR = glomerular filtration rate, OR = odds ratio, CI = confidence interval, BMI = body mass index, HbA1c = hemoglobin A1c, HbsAg = hepatitis B virus surface antigen.