Table 1.
Type of adjuvant and aluminum content of aluminum-adjuvanted vaccines licensed for use in the United States (Information accessed on FDA website on May 24, 2018 (https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm093833.htm))
Vaccine | Tradename | Manufacturer | Adjuvant | Dose (Al3+) |
---|---|---|---|---|
Anthrax | BioThrax® | Emergent Biosolutions | AH | 1.2 mg |
Diphtheria and Tetanus Toxoids Adsorbed | Sanofi-Pasteur | AP | 0.33 mg | |
DTaP | Daptacel® | Sanofi-Pasteur | AP | 0.33 mg |
Infanrix® | GSK | AH | ≤0.625 mg | |
DTaP, Hepatitis B, polio | Pediarix® | GSK | AH | ≤0.85 mg |
DTaP, polio | Kinrix® | GSK | AH | ≤0.6 mg |
Quadracel® | Sanofi-Pasteur | AP | 0.33 mg | |
DTaP, polio, Hib | Pentacel® | Sanofi-Pasteur | AP | 0.33 mg |
Hib | PedVaxHIB® | Merck | AAHS | 0.225 mg |
Hepatitis A | Havrix® | GSK | AH | 0.5 mg (adult) |
0.25 mg (pediatric) | ||||
VAQTA® | Merck | AAHS | 0.45 mg (adult) | |
0.225 mg (pediatric) | ||||
Hepatitis A and Hepatitis B | Twinrix® | GSK | AH and AP | 0.45 mg |
Hepatitis B | Engerix | GSK | AH | 0.5 mg (adult) |
0.25 mg (pediatric) | ||||
Recombivax HB® | Merck | AAHS | 0.5 mg (adult) | |
0.25 mg (pediatric) | ||||
Human papilloma virus | Cervarix® | GSK | AH | 0.5 mg (plus 50 µg MPLA) |
Gardasil® | Merck | AAHS | 0.225 mg | |
Gardasil-9® | Merck | AAHS | 0.5 mg | |
Meningococcus B | Bexsero® | GSK | AH | 0.519 mg |
Trumenba® | Pfizer | AP | 0.25 mg | |
Pneumococcus | Prevnar 13® | Pfizer | AP | 0.125 mg |
Tetanus and Diphtheria Toxoids, Adsorbed | Tenivac® | MassBiologics | AP | ≤0.53 mg |
Sanofi-Pasteur | AP | 0.33 mg | ||
TdaP | Adacel® | Sanofi-Pasteur | AP | 0.33 mg |
Boostrix® | GSK | AH | ≤0.39 mg |
DTaP diphtheria toxoid, tetanus toxoid, acellular pertussis, Hib Haemophilus influenzae B, TdaP tetanus toxoid, reduced diphtheria toxoid, acellular pertussis, AH aluminum hydroxide adjuvant, AP aluminum phosphate adjuvant, AAHS amorphous aluminum hydroxyphosphate sulfate