Table 2.

Examples of aluminum-containing combination adjuvants in vaccines licensed for use or under clinical development (not comprehensive)

Molecular adjuvant (receptor)	Aluminum adjuvant	Indication(s)	Development stage
MPL® (TLR4)	AH or AP	Human papilloma virus, Hepatitis B	Licensed (Cervarix®, Fendrix®)
CpG (TLR9)	AH	Malaria, Hookworm, Nicotine	Phase 2
GLA (TLR4)	AH	Hookworm	Phase 1
LHD153R (TLR7)	AH	Meningococcus	Phase 1
QS-21	AH	HIV	Phase 1
IL-12	AH	Leishmaniasis	Phase 1

AH aluminum hydroxide adjuvant, AP aluminum phosphate adjuvant