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. 2018 Oct 10;50(10):133. doi: 10.1038/s12276-018-0157-3

Fig. 3. Cosmc deficiency results in accumulation of zymogen granules and pancreas atrophy in aged mice.

Fig. 3

a Representative TEM and brightfield micrographs of pancreas sections from fasting WT and Cosmc-KO adult mice. Zymogen granules are depicted as electron dense vesicles. TEM and BF scale bars are 2 and 20 µm, respectively. b Quantification of zymogen granules in five randomly selected fields of pancreas sections from fasting WT and Cosmc-KO adult mice (n = 5 each). Elevated numbers of zymogen granules in Cosmc-KO pancreata (P = 0.0004). c WB of VVA pull-down from WT and Cosmc-KO pancreatic lysates and DMBT1-specific antibody for detection. d Body weight analysis of WT and Cosmc-KO mice at ages 2–48 weeks (n = 10 each) displays reduced body weight gain at 2 and 4 weeks of age (P = 0.0021 and P = 0.0002). e Assessment of pancreas organ weight of 20- (n = 10) and 54-week-old WT (n = 11) and Cosmc-KO (n = 13) mice. Aged mice display reduced organ weight (P = 0.0062)