Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Oct 10;9:4188. doi: 10.1038/s41467-018-06592-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 6 — PRC2 mutations suppress accumulation of pathogenic polyglutamine protein. a Animals expressing SCA3trQ78 in the photoreceptor cells have prominent nuclear inclusions. 3d animals, antibody to HA tag present on the SCA3trQ78 transgene (green). Dapi (blue), nuclei. Genotype: rh1-GAL4, UAS-SCA3trQ78/+. Scale bar indicates 10 μm. b Decreasing Pcl activity decreased SCA3trQ78 inclusions of 3d animals. Genotype: Pcl⁵/+; rh1-GAL4, UAS-SCA3trQ78/+. c Decreasing Su(z)12 activity decreased SCA3trQ78 inclusions of 3d animals. Genotype: rh1-GAL4, UAS-SCA3trQ78/Su(z)12². d Average number of inclusions detected in the region of interest in various genotypes. Mean ± SEM, n = 3 animals, using the average of at least 4 sections per animal. F_2,6 = 27.84, p < 0.001, one-way ANOVA, with Tukey post-test **p < 0.01. e Mean size of inclusions. The size of inclusions detected in at least 4 sections per animal was determined, with the control cohort adjusted to 100%. The average size of inclusions was smaller in animals heterozygous for Pcl⁵ or Su(z)12². Mean ± SEM, n = 3 animals, using the average of at least 4 sections per animal. F_2,6 = 30.89, p < 0.001, one-way ANOVA, with Tukey post-test, **p < 0.01