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. 2018 Oct 10;8:15075. doi: 10.1038/s41598-018-33479-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Overall structure of OvTIM. (a) Overall dimeric structure of OvTIM. The bundle of α-helices and β-barrel of OvTIM are represented as green and orange cartoon models, respectively. The SAD motif is denoted as a yellow sphere model. (b) The top view and (c) rotation view of the monomer of OvTIM are displayed. Hydrophobic residues forming the β-barrel fold are represented as a stick model. The catalytic triad, SAD motif, and dimerization loop are highlighted as cyan, yellow, and magenta, respectively.