Table 1.
Association statistics for two independent SNP genotypes and WM/LPL risk
| Nearest gene | SNP | Positiona | Variant Effb/Oth | Stage | EAF controls | Cases/controls n/n | OR | (95% CI) | P-value |
|---|---|---|---|---|---|---|---|---|---|
| 6p25.3 | |||||||||
| EXOC2 | rs116446171 | 484453 | G/C | Stage 1 | 0.0191 | 217/3798 | 56.44 | (32.89, 96.85) | 1.59E−48 |
| Stage 2 | 0.0195 | 312/564 | 7.71 | (4.46, 13.33) | 2.54E−13 | ||||
| Combined | 529/4362 | 21.14 | (14.40, 31.03) | 1.36E−54 | |||||
| 14q32.13 | |||||||||
| Intergenic | rs117410836 | 96051974 | C/T | Stage 1 | 0.0266 | 217/3798 | 10.62 | (6.17, 18.29) | 1.63E−17 |
| Stage 2 | 0.0355 | 306/563 | 2.81 | (1.77, 4.45) | 1.16E−05 | ||||
| Combined | 523/4361 | 4.90 | (3.45, 6.96) | 8.75E−19 |
For stages 1 and 2, P-values were generated using logistic regression. For the combined stage, the odds ratio and P-values were generated using a fixed-effects model controlling for age, gender and genotyping center
WM Waldenström macroglobulinemia, LPL lymphoplasmacytic lymphoma, SNP single-nucleotide polymorphism, Eff effect, Oth other, EAF effect allele frequency, n number, OR odds ratio, CI confidence interval
aGenome coordinates are from NCBI human genome GRCh37/human genome (hg) build 19
bVariant associated with an effect on risk of WM/LPL