Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Oct 10;9:4189. doi: 10.1038/s41467-018-06666-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 3 — ESC-specific H3K27me3 homotypic interactions require PRC1. a Number of wild-type homotypic interactions (involving the indicated proteins/modifications) found in Ring1A KO or Ring1A/B DKO ESCs. b Strength of the preserved homotypic interactions (measured as log2 observed/expected PCHi-C signal) in Ring1A KO or Ring1A/B DKO ESCs. ***p < 0.0005 (t-test, corrected for multiple KO-DKO comparisons). c Expression ratio (log2) between Ring1A/B DKO and Ring1A KO ESCs for genes involved in either H3K27me3 or CTCF homotypic interactions (all or ESC-specific), and compared with genes not involved in homotypic interactions. ***p < 0.0005 (t-test). d Interaction profiles in Ring1A KO or Ring1A/B DKO ESCs for the regions highlighted in Fig. 2e, f. e Expression ratio between Ring1A/B DKO and Ring1A KO ESCs for TSC-expressed genes involved in the interactions highlighted in d. Boxplot midline represents median, box edges the first and third quartiles, and whisker edges are the last data points within 1.5× the interquartile range