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. 2018 Oct 10;9(10):1037. doi: 10.1038/s41419-018-1105-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Plasma miR-486-5p was significantly higher in CRC patients than that in healthy individuals. b MiR-486-5p were significantly downregulated after operation. c MiR-486-5p expression levels in the medium of HT29 and SW480 cells increased with increasing cell counts and incubation time. d The diagnostic utility of plasma miR-486-5p in CRC analyzed by ROC curve. e The expression of exosomal miR-486-5p was remarkably lower in CRC cell lines than that in FHC. f Exosomal miR-486-5p expression was significantly higher in the medium of CRC cells than that in the medium of FHC. g Circulating exosomal miR-486-5p expression was statistically upregulated in CRC patients with various stages. h The diagnostic utility of circulating exosomal miR-486-5p in CRC analyzed by ROC curve. Data are represented as means ± S.D. from at least three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001