Fig. 4.

Silencing dorsal or ventral adult-born neurons impairs expression of context fear. a Cre⁺ mice (Dorsal: n = 18; Ventral: n = 14) and Cre^– littermates (Dorsal: n = 23; Ventral: n = 19) were fear conditioned with the Light Off and then tested in the training context and a similar alternate context with the Light On. b Baseline (preshock) freezing was uniformly low. c Distance traveled during the shock was comparable between the groups. d Silencing Dorsal or Ventral adult-born neurons reduced freezing in both the original and similar contexts (F_1,70 = 25.139, p < 0.001). All groups froze more in the original than the similar context (F_1,70 = 54.480, p < 0.001). e All groups discriminated significantly better than chance (p’s ≤ 0.008). Silencing the dorsal and ventral adult-born neurons significantly enhanced discrimination (F_‘1,70 = 7.289, p = 0.009). Error bars represent ±1 SEM