Fig. 5.

Silencing adult-born neurons does not impair expression of hippocampus-independent fear. a To determine whether silencing adult-born neurons impairs hippocampus-independent conditioned fear, mice with ventral implants (Cre⁺: n = 4; Cre^–: n = 4) received tone-shock pairings with the Light Off. Tone-elicited fear was tested in a different context twice, first with the Light On and then with the Light Off. b Baseline (preshock) freezing was uniformly low. c Distance traveled during the shock was comparable between the groups. d, e There was no effect of Genotype during the Light On test (d) or the Light Off test (e). During both test sessions, tone freezing exceeded baseline (pre-tone) freezing (F_1,6 = 70.589, p = 0.002). Error bars represent ±1 SEM