Fig. 2.

Constitutive PKMζ knockout potentiates food self-administration without altering cue-induced food seeking. PKMζ KO_CONSTITUTIVE mice earn more pellets (a) and exhibit significantly greater responding (b) than wildtype mice during a 1 h food self-administration session. While both wildtype and PKMζ KO_CONSTITUTIVE mice exhibit a significant increase in responding during reinstatement (c), there were no differences between the groups. *p < .05, effect of genotype (a, b; n = 22/group); **p < .01, effect of session (c; n = 6–8/group; 2-h session)