Fig. 3.
Constitutive PKMζ knockout potentiates cocaine self-administration and cue-induced cocaine seeking. Although the groups did not differ in the number of cocaine infusions (a), PKMζ KOCONSTITUTIVE mice exhibited significantly greater responding during both cocaine self-administration (b) and cue-induced reinstatement (d; 2-h session). No differences were seen in the time it took for the groups to extinguish the cocaine seeking behavior (c). **p < .01, effect of genotype (b; n = 12–15/group); pairwise comparison WT vs. KO (c; n = 8–16/group)