Table 1.
Enriched pathways involved in development obtained from PANTHER pathway analysis of target genes of differentially expressed miRNAs
| Serial no. | Pathway Name (Accession) | Genes | Percent of gene hit against total genes | Percent of gene hit against total pathway hits |
|---|---|---|---|---|
| 1 | Wnt signaling pathway (P00057) | 54 | 1.90% | 5.20% |
| 2 | Gonadotropin-releasing hormone receptor pathway (P06664) | 42 | 1.50% | 4.10% |
| 3 | CCKR signaling map (P06959) | 33 | 1.20% | 3.20% |
| 4 | Inflammation mediated by chemokine and cytokine signaling pathway (P00031) | 32 | 1.10% | 3.10% |
| 5 | Angiogenesis (P00005) | 31 | 1.10% | 3.00% |
| 6 | PDGF signaling pathway (P00047) | 27 | 1.00% | 2.60% |
| 7 | EGF receptor signaling pathway (P00018) | 26 | 0.90% | 2.50% |
| 8 | Integrin signalling pathway (P00034) | 23 | 0.80% | 2.20% |
| 9 | Alzheimer disease-presenilin pathway (P00004) | 22 | 0.80% | 2.10% |
| 10 | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway (P00026) | 22 | 0.80% | 2.10% |
| 11 | Apoptosis signaling pathway (P00006) | 21 | 0.70% | 2.00% |
| 12 | p53 pathway (P00059) | 21 | 0.70% | 2.00% |
| 13 | Huntington disease (P00029) | 21 | 0.70% | 2.00% |
| 14 | Cadherin signaling pathway (P00012) | 20 | 0.70% | 1.90% |
| 15 | Parkinson disease (P00049) | 19 | 0.70% | 1.80% |
| 16 | FGF signaling pathway (P00021) | 17 | 0.60% | 1.60% |
| 17 | p53 pathway feedback loops 2 (P04398) | 16 | 0.60% | 1.50% |
| 18 | Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway (P00027) | 16 | 0.60% | 1.50% |
| 19 | TGF-beta signaling pathway (P00052) | 15 | 0.50% | 1.50% |
| 20 | Interleukin signaling pathway (P00036) | 15 | 0.50% | 1.50% |
| 21 | Cytoskeletal regulation by Rho GTPase (P00016) | 15 | 0.50% | 1.50% |
| 22 | Ubiquitin proteasome pathway (P00060) | 13 | 0.50% | 1.30% |
| 23 | PI3 kinase pathway (P00048) | 13 | 0.50% | 1.30% |
| 24 | Nicotinic acetylcholine receptor signaling pathway (P00044) | 13 | 0.50% | 1.30% |
| 25 | Muscarinic acetylcholine receptor 2 and 4 signaling pathway (P00043) | 13 | 0.50% | 1.30% |
| 26 | Dopamine receptor mediated signaling pathway (P05912) | 13 | 0.50% | 1.30% |
| 27 | T cell activation (P00053) | 12 | 0.40% | 1.20% |
| 28 | Insulin/IGF pathway-protein kinase B signaling cascade (P00033) | 12 | 0.40% | 1.20% |
| 29 | Cell cycle (P00013) | 12 | 0.40% | 1.20% |
| 30 | Metabotropic glutamate receptor group III pathway (P00039) | 11 | 0.40% | 1.10% |