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. 2018 Oct 10;50(10):132. doi: 10.1038/s12276-018-0160-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a–c The phosphorylation status in the activation loops of purified wild-type and phosphomimetic MSK1 with a single (a), double (b), and triple (c) number of mutant fragments was monitored by immunoblotting with anti-S212 and anti-T581 phospho-specific antibodies. MSK1 and MSK1* wild-type MSK1 were prepared in the absence and presence of MKK6ca co-expression, respectively. The data are representative of at least three independent experiments. MSK1 phosphomimetic mutants with active histone kinase activity (Fig. 4) are indicated by underlining