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. 2018 Oct 4;9:431. doi: 10.3389/fgene.2018.00431

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Copyright © 2018 Karamyshev and Karamysheva.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Model for regulation of aberrant protein production (RAPP) in mammalian cells. Normal cotranslational interactions are important for protein biogenesis. Nascent chains of secretory proteins interact with signal recognition particle (SRP). This interaction leads to proper protein targeting to ER, folding and transport (A). Loss of this normal interaction with SRP due to a critical mutation in the secretory protein (B) or loss of the interacting factor (C) leads to engagement of AGO2 (a protein involved in translational silencing). This interaction directs aberrant protein mRNA for degradation initiating the RAPP process.