Table 4.
Comparison of rheumatoid arthritis (RA)-susceptible, resistant and non-association alleles in the DRB1*04 group sequences.
| Statistical information of Oka et al. [47] | Allele name at the full-length level | Amino acid position in exon 2 | Nucleotide position in intron 2 | Presence of AluYk2 in intron 1 | Presence of L1PA4 in intron 1 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Allele name | P-value | OR (95% CI) | 67 | 68 | 69 | 70 | 71 | 72 | 73 | 74 | 9139 | 9304 | |||
| DRB1*04:05 | 1.4 × 10e-36 |
3.3 (2.73–4.01) |
DRB1*04:05:01:01 | L | L | E | Q | R | R | A | A | G | A | (+) | (+) |
| DRB1*04:05:01:02 | (+) | (+) | |||||||||||||
| DRB1*04:05:01:03 | (+) | (+) | |||||||||||||
| DRB1*04:01 | 4.3 × 10e-5 |
2.8 (1.63–4.70) |
DRB1*04:01:01:03 | L | L | E | Q | K | R | A | A | G | A | (+) | (+) |
| DRB1*04:10 | 0.01 | 1.8 (1.12–3.02) |
DRB1*04:10:03 | L | L | E | Q | R | R | A | A | G | A | (+) | (+) |
| DRB1*04:06 | 0.0005 | 0.5 (0.35–0.74) |
DRB1*04:06:01 | L | L | E | Q | R | R | A | E | A | G | (+) | (+) |
| DRB1*04:03 | 0.0012 | 0.5 (0.30–0.74) |
DRB1*04:03:01:02 | L | L | E | Q | R | R | A | E | A | G | (+) | (+) |
| DRB1*04:07 | 0.0001 | 0.1 (0.05–0.43) |
DRB1*04:07:01:02 | L | L | E | Q | R | R | A | E | A | G | (+) | (+) |
| Other alleles | LIF | L | E | QRD | RKEA | R | AG | AEQLR | G | – | – | – | |||
RA-susceptible (red) and resistant (blue) alleles are shown in this table. Amino acid and nucleotide positions are bases on the sequence alignment tool of the IPD-IMGT/HLA database (https://www.ebi.ac.uk/ipd/imgt/hla/align.html) using the DRB1*04 group sequences shown in Figure S4 in Supplementary Material. The Bold letter indicates a difference of the amino acid or nucleotide sequence between the RA susceptible and resistant alleles. Amino acid positions in the exon 2 were referred from (47–51).